About This Course

Alagille syndrome (ALGS) is a rare, multisystem disorder that can affect the liver, heart, skeleton, eyes, vasculature, and kidneys. It is one of the most common inherited causes of neonatal cholestasis. Symptoms and severity can vary greatly from one person to another even within the same family, which makes diagnosis difficult. In symptomatic infants with cholestasis or severe organ involvement, ALGS often presents during the first 3 months of life. However, in those with a milder phenotype it is often not diagnosed until later in childhood or, less frequently, in adulthood.

This short course has been designed to teach healthcare providers everything they need to know about Alagille syndrome in order to increase recognition and improve patient care. It should take you 30-60 minutes to complete.

Learning Outcomes

By the end of this course, you should be able to:

  • describe in context the epidemiology, pathogenesis, and burden of disease of ALGS.

  • identify the clinical symptoms indicative of ALGS.

  • explain the significance of genetic testing for the ALGS diagnosis.

  • summarize investigations frequently used for the diagnosis of ALGS.

  • apply knowledge of ALGS to improve management and patient care.

Expert Faculty

This course has been made in close collaboration with:

Course curriculum

    1. Welcome to the Course

    1. Introduction to Precourse Quiz

    2. Precourse Quiz

    1. What is Alagille Syndrome?

    1. Diagnosis of Alagille Syndrome

    1. Management of Alagille Syndrome

    1. Introduction to Final Quiz

    2. Final Quiz

    1. Conclusions and Take-Home Messages

    2. Course Feedback Survey

About this course

  • Free
  • 10 lessons
  • 0 hours of video content

This course has been funded by unrestricted educational grants from Mirum Pharmaceuticals, Inc. and Albireo Pharma, Inc. They have had no control over the content of this resource.

If you are interested in other liver diseases, see our course on PFIC

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